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It is important to know this for patients desiring autologous transfusion (receiving one’s own blood), as red cell survival may be an issue. In hemolytic anemia, the cell life span may be shorter. Mature RBCs have a lifespan of about 120 days. Mild polycythemia may be corrected by increasing vascular fluid volume, while more severe cases require frequent phlebotomies or even radiation or chemotherapy to suppress bone marrow production. Polycythemia vera, a pathologic condition which is a proliferative disease of the bone marrow, causes an increase in total RBCs as well as an elevation in white cells and platelet count. Normal levels in men and women are 4.6 million-5.9 million and 4.1 million-5.4 million, respectively. Increases may be found when one moves to a higher altitude or after prolonged physical exercise, and can also reflect the body’s attempt to compensate for hypoxia. The RBC count will be low with iron deficiency, blood loss, hemolysis and bone marrow suppression. Red blood cells: RBCs are the number of erythrocytes in 1 cubic mm of whole blood. Usually, platelets will also be checked with the CBC. The CBC tests for the amount of RBCs, hemoglobin, hematocrit, reticulocytes, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. When blood oxygen is low, erythropoietin stimulates the bone marrow to produce more RBCs.

Red blood cell production is regulated by erythropoietin, a hormone released by the kidneys. Cells of the blood include the erythrocytes, which are the red blood cells (RBC) the leukocytes, which are the WBC and the thrombocytes, also known as platelets.īlood cells are produced in the bone marrow by a process called hematopoiesis. The cells are the blood components that will be discussed in this review.

Plasma makes up more than half of the total blood volume. The plasma consists of water, plasma proteins (a few of which are serum albumin and globulin and fibrinogen), and other constituents. Plasma is the liquid part of the blood in which the formed cells are suspended. Most of us are well acquainted with hemoglobin, hematocrit and white blood cells (WBC), but perhaps the rest of those numbers are insignificant to the particular patient being tested … or are they? What is the meaning of those other components of the CBC and diff? Blood Componentsīlood is made of two major components-plasma and cells. If you don’t use it you lose it! That aptly applies to interpreting the complete blood count (CBC) and differential (diff).

Hemoglobin, hematocrit and WBC are just the beginning–don’t overlook erythrocytes, leukocytes and thrombocytes for important assessment data.